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briscoe laboratory

Our Team

Summary of Our Research

Transplantation is widely recognized as the treatment of choice for end-stage organ disease in children. Nevertheless, despite significant advances in immunosuppressive therapeutics to prevent acute rejection, long-term graft survival remains suboptimal.

Our research is based on the critical need to develop a greater understanding of immune responses that both promote and inhibit allograft rejection. The laboratory is focused on mechanistic studies that define the state of the alloimmune response as well as an understanding of how the graft itself may dictate the process of inflammation/rejection vs immune evasion/proresolution.

Our studies focus on three broad areas including:

How events within the intragraft microenvironment including leukocyte-endothelial cell interactions promote, sustain, or inhibit T cell activation and allorecognition

Discrete signals and molecular interactions in select populations of T cells that are integral to inflammation resolution

The application of these discoveries into the development of biomarkers and new therapeutics to transform clinical care and improve outcomes following transplantation

Active Projects Include

The Intragraft Microenvironment and the Development of RejectioN

Allograft rejection is associated with persistent mononuclear cell recruitment, endothelial cell activation and proliferation and related biology that enhance effector immune responses. In our previous studies, we provided some of the first evidence that endothelial cells contribute to this pro-inflammatory response.  Our current research is focused on the identity of factors that enable the endothelial cell to shape the intragraft microenvironment either towards local inflammation or local immune evasion and immunoregulation. Ongoing studies focus on regulatory signaling within the vascular endothelial cells that promote the expression of cell surface and/or secreted molecules that are critical for long-term graft survival and/or alloimmune tolerance. Our findings have led to the identity of discrete signals and novel families of molecules within graft endothelial cells that favor immune evasion and local immunoregulation. We are currently testing this biology using sophisticated in vitro cell culture models as well as established pre-clinical in vivo models of transplant rejection or tolerance.

Discrete Signals and Molecular Interactions in Select Populations of T Cells 

TSAd: Once T cells encounter alloantigen, they undergo expansion and differentiation into effectors and/or memory T cells. However, activation also results in the expansion of regulatory T cells that function to control the immune response, and it is proposed that this process of immunoregulation is critical for long-term allograft survival. Within T cells, several adapter proteins including TSAd have been found to be active participants in signaling responses that modulate T cell activation and immunoregulation. We find that the relative activity of TSAd is critical for T regulatory cell activation, and we reported that its absence is associated with resistance to costimulatory blockade in vivo.

Neuropilin-2: This project is based on initial observations in which we reported that the binding of semaphorin-3F to its receptor neuropilin-2 results in the inhibition of Akt and mTOR activity. Thus, neuropilin-2-dependant signaling in select immune cell types is likely of great significance in the resolution of inflammation. In our ongoing studies, we have developed novel transgenic mice for the analysis of neuropilin-2 dependent biology in transplant rejection.

DEPTOR: DEPTOR is an evolutionarily conserved and first-in-kind cell intrinsic factor that was discovered as an mTOR-binding partner that regulates cellular activation. In our studies, we identified its expression within CD4+ T cells, and we find that it has striking effects to modulate mTORC1 signaling activity. Following cellular activation, DEPTOR is rapidly phosphorylated and targeted for ubiquitination and degradation, thus removing its negative/regulatory effects on the intracellular signaling/activation response. In ongoing studies, we have reported that sustained levels of DEPTOR expression within CD4+ Foxp3+ T regulatory cells promotes immunoregulation and long-term graft survival following fully MHC mismatched cardiac transplantation. Ongoing studies are addressing whether DEPTOR has additional effects in the immune response, and how its biological effects in additional immune cells.

Clinical Trial Initiatives

There is a great need to study unique alloimmune, genomic, and age-specific biology in pediatric patients following renal transplantation. For many years, Dr. Briscoe’s laboratory has developed and validated biomarkers to identify transplant recipients at risk of acute or chronic rejection. The laboratory has also had a long-standing involvement in innovative clinical trials that include advanced mechanistic studies and biomarker use to evaluate efficacy of novel therapeutics. Currently, Dr. Briscoe is the Principal Investigator of a consortium U01 grant to evaluate the therapeutic efficacy of costimulatory blockade therapeutics following pediatric renal transplantation. Planned collaborative studies will be performed in multiple sites within the US to evaluate the targeting of both cellular and humoral alloimmune responses, immunoregulation as well as pathogen-specific and protective immune responses in trial recipients.

Briscoe Lab Team

Administrator

Ciara Jacques, BA

Research Administrator

Ciara received a Bachelor’s degree in Philosophy from Boston University. Her previous experience includes grant management at a multicultural non-profit. She joined the Transplant Research Program as a Research Administrator.

ciara.jacques@childrens.harvard.edu

 

Research Fellows

Sayantan Bose, PhD

Research Fellow

Bose received his PhD from the University of Calcutta in 2020 for studies on tumor immunity with a particular focus on regulatory T-cells and their modulation by micro-RNAs. He is studying the intracellular mechanisms involved in the function of NRP-2 and DEPTOR, both regulators of the mTOR pathway in immune cells.

sayantan.bose@childrens.harvard.edu

Masaki Komatsu, MD, PhD

Research Fellow

Masaki received his MD from Kanazawa Medical University in Ishikawa, Japan, in 2011. He then trained in General Surgery and Cardiovascular Surgery. In 2023, he received his PhD in Medicine from Shinshu University in Matsumoto, Japan. Masaki is working in the Briscoe Laboratory as a microsurgeon supporting ongoing research studies. His main project relates to understanding the role of allograft endothelial cells in promoting long-term graft survival.

masaki.komatsu@childrens.harvard.edu

Suchita Jadhav, MSc, PhD

Research Fellow

Suchita received her Master of Science in Biotechnology from the University of Pune, Maharashtra, India in 2016. In 2024, she received her PhD in Immunology and Cancer Biology from Ariel University in Israel for her work in Prof. Michael Firer’s laboratory on modeling the cellular immune responses during progression from premalignant to active multiple myeloma. Suchita joined the Briscoe Laboratory and will study mechanisms by which endothelial cells may regulate the alloimmune response.

suchita.jadhav@childrens.harvard.edu

 

Clinical CoordinatorS

Emily Toal, MPH

Clinical Coordinator

Emily received her Bachelor’s degree in Health Behavior Science with minors in Business Administration and Public Health from the University of Delaware in 2018, she then worked as a Clinical Research Coordinator in Philadelphia for 3 years, specializing in liver disease. She now works as a Clinical Research Specialist in the Transplant Research Program, and has received her Masters of Public Health at Boston University, specializing in Epidemiology and Biostatistics in Chronic Diseases.

emily.toal@childrens.harvard.edu

Margaret Diehl, RN

Coordinator

Maggie received her undergraduate degree from Stonehill College and her RN from Northeastern University. She provides support for the Advantage Clinical Trial.

margaret.diehl@childrens.harvard.edu

 

Laboratory Assistants

Jessica Leyva-Rangel, PhD

Laboratory Assistant

Jessica received her PhD in Molecular Biomedicine from the National Autonomous University of Mexico, Mexico City, in 2015. Her focus of study was T cell development and selection during infection. Over the course of her studies she worked extensively with transgenic mice and has developed insight into the expansion of distinct T cell populations in the course of infectious disease. Upon relocation to Boston, Jessica was recruited to the Briscoe Laboratory as a Research Technologist and she supports Laboratory activities including the development, phenotyping and maintenance of transgenic mice.

jessica.leyva-rangel@childrens.harvard.edu

Vicki Do

Laboratory Assistant

Vicki received a Bachelor of Science degree in Biology and Philosophy at Tufts University in 2023.  She joined the Briscoe and Wedel laboratories as research assistant supporting big data analysis. Vicki is broadly interested in evaluating immunoregulatory mechanisms using multi-omics approaches. She has aspirations to attend medical school in the future and pursue a career in nephrology.

vicki.do@childrens.harvard.edu

Madeleine Boone, BA

Research Assistant

Madi received a bachelor’s degree in Anthropology from Vassar College in 2021 and joined the Briscoe laboratory in January 2024. Madi is currently learning general immunology lab techniques.

madeleine.boone@childrens.harvard.edu

 

Gallery

2020

2018

2016

2013

2006-2011

2001-2003

Alumni

Past Research Fellows

In total Dr. Briscoe has trained over 40 postdoctoral fellows, the majority of whom still maintain their own research efforts.

Three trainees successfully defended their MD/PhD theses, several trainees received notable awards and research grants for their work including NIH K and/or NIH loan repayment grants.

Approximately one third currently direct R01-funded or equivalent research laboratories. Of those in the USA, over one half serve as clinician or scientific investigators.

One past trainee is an elected member of the American Society for Clinical Investigation, two are Pediatric Nephrology Division Chiefs and one is a Director of a Department of Pediatrics.

A full list of past research fellows in the laboratory can be found by clicking the link below:

Past Mentored MD and PhD + MD/PhD Trainees

1994 – 1995 Michelle Baum, MD
Current Position: Assistant Professor of Pediatrics, Harvard Medical School.
Career Stage: Pediatric Nephrology Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

1995 – 1997 Ross Reul, MD
Current Position: Assistant Program Director, Thoracic Surgery Residency Program, Texas Heart Institute, Houston, Texas.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

1995 – 1998 Stephen I Alexander, MD
Current Position: Chief, Pediatric Nephrology, Westmead Children’s Hospital, Sydney, Australia.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

1996 – 1998 Vikas Dharnidharka, MD
Current Position: Chief, Pediatric Nephrology and Associate Professor of Pediatrics, Washington University at St Louis, St Louis Children’s Hospital, St Louis, MO
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Young Investigator Award from the AST (1998), Young Investigator Award from the NAPRTCS (1998), R01-funded Investigator.

1996 – 1999 Mark Denton, MD
Current Position: Consultant Nephrologist, Beaumont Hospital, Dublin, Ireland.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, NIH K08 grant, Young Investigator Award from the AST (1998, 1999).

1998 – 2000 Andrea Exeni, MD
Current Position: Staff Pediatrician, Children’s Hospital, Buenos Aires, Argentina.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

1998 – 2000 Michael Melter, MD
Current Position: Chair of Pediatrics, University of Regensburg, Regensburg, Germany.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Young Investigator Award from the AST (1998).

1998 – 2000 Peter Shaw, MD. Deceased.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Faculty at the University of Arizona, Phoenix.

1999- 2001 Markus Frank, MD
Current Position: Associate Professor of Pediatrics, Harvard Medical School.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Research career development, Young Investigator Award from the AST (2000), International Pediatric Transplant Association Award (IPTA) (2001), Past Co-Mentored K Award Faculty, elected member of the American Society of Clinical Investigation, R01- funded Investigator.

1999 – 2002 Dmitry Samsonov, MD
Current Position: Chief, Pediatric Nephrology and Assistant Professor of Pediatrics, Maria Fareri Children’s Hospital, Valhalla, New York.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, American Society of Transplantation (AST) Basic Research Fellowship Grant, Young Investigator Award from the AST (2001).

1999 – 2002 Masayuki Sho, MD/PhD
Current Position: Staff Surgeon, Nara University, Nara, Japan.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Young Investigator Award from the ATC (2001, 2002), International Young Investigator Award from the ATC (2003, 2004, 2005).

2000 – 2002 Marlies Reinders, MD. PhD
Current Position: Professor, University of Leiden, Leiden Holland; Staff Nephrologist, Leiden Univ. Medical Center, Leiden, Holland.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, International Pediatric Transplant Association Award, Young Investigator Award from the ATC, PhD Thesis Defense/2004. Currently: EU- multicenter clinical trial funded Investigator.

2000 – 2002 Ingrid Vos, PhD
Current Position: Staff Scientist, Utrecht Veterinary College, Utrecht, The Netherlands.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

2000 – 2003 Peter Lapchak, PhD
Current Position: Instructor in Medicine, Harvard University, Beth Israel Deaconess Medical Center, Boston, MA.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, National Kidney Foundation Fellowship Grant (2002-2003).

2002 – 2004 Stefan Kiessling, MD
Current Position: Chief, Pediatric Nephrology and Associate Professor of Pediatrics, University of Kentucky.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

2002 – 2005 Jesse Flaxenburg, MD
Current Position: Consultant Nephrologist, Colorado Springs, CO.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, NIH F32 NRSA Grant (2003-2005), NHLBI Loan Repayment Grant (2003-2004).

2002 – 2005 Stuart Robertson, MD
Current Position: Consultant in Renal Medicine, University of Cardiff, Wales.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research. National Kidney Foundation Pediatric Renal Research Fellowship Grant (2003-2004).

2002 – 2006 Gwen Boulday, PhD
Current Position: Research Scientist, INSERM, University of Paris, France.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Young Investigator Award from the AST (2003, 2004), Foundation grants from the EU/France. INSERM.

2003 – 2005 Zdenka Haskova, MD.PhD
Current Position: Associate Medical Director, Genentech, San Francisco, CA.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Young Investigator Award from the AST (2005).

2003 – 2006 Sreevinas Laxmanan, PhD
Current Position: Staff Scientist, Biogen IDEC, Cambridge, MA.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

2003 – 2007 Olivier Dormond, MD.PhD
Current Position: Staff, Internal Medicine/Nephrology, University of Lausanne, Switzerland.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Swiss Foundation for Grants in Medicine and Biology Fellowship Grant (2006-2008), Young Investigator Award from the WTC (2006).

2003 – 2010 Dipak Datta, PhD
Current Position: Research Scientist, Drug Target Discovery and Development Division, Central Drug Research Institute (CDRI-CSIR), Lucknow, India.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Young Investigator Award from the ATC (2007, 2010).

2005 – 2009 Aninda Basu, PhD
Current Position: Research Assistant Professor, University of Illinois, Chicago.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

2006 – 2008 Monika Edelbauer, MD
Current Position: Pediatric Nephrology, University Hospital, Innsbruck, Austria.
Career Stage: Fellow. Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Austrian Science Fund Travel Fellowship Grant (2006-2008).

2006 – 2008 Andre Hoerning, MD
Current Position: Faculty, Pediatric Nephrology, Children’s Hospital, Essen, Germany.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Deutsche Forschungsgemeinschaft (DFG) Fellowship Grant (2007-2009).

2006 – 2010 Xiao Wu, PhD
Current Position: Pursuing Pathology residency, University of Massachusetts, Worcester.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

2007 – 2009 Michael Seifert, MD
Current Position: Associate Professor, University of Alabama at Birmingham.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, NIH K12 grant, NIH K23 Career Development grant, Loan Repayment Grant (2012-2015).

2008 – 2010 Maria Stack, MD
Current Position: Attending in Pediatric Nephrology, Children’s Hospital, Temple St, Dublin, Ireland.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, PhD Thesis/Defended 2015.

2008 – 2010 Tatsuichiro Seto, MD/PhD
Current Position: Staff Cardiothoracic Surgeon, Shinshu University, Shinshu, Japan.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

2009 – 2010 Papia Banerjee, PhD
Current Position: Research Scientist, Dana-Farber Cancer Institute.
Career Stage: Research Associate
Mentoring Role: Mentor.
Accomplishments: Career Development training/Authored scholarship.

2009 – 2013 Sarah Bruneau, PhD
Current Position: Postdoctoral Scientist, INSERM, Nantes, France.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Foundation Bettencour-Schueller Post Doctoral Fellowship Award (2010), American Society of Transplantation Fellowship Grant Award (2010-2012), Young Investigator Award from IPTA (2013), Scientist Level Grants from the EU/France.

2010 – 2012 Kevin Daly, MD
Current Position: Assistant Professor in Pediatrics, Harvard Medical School.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research. Grants and Awards: Co-PI, Harvard Catalyst Grant, Young Investigator Award from the ATC (2011), NIH Loan Repayment Grant (2011-2015).

2010 – 2013 Craig Woda, MD. PhD
Current Position: Assistant in Medicine, Boston Children’s Hospital.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

2010 – 2017 Leo Boneschansker, MD. PhD
Current Position: Resident in Medicine, Massachusetts General Hospital.
Career Stage: Graduate Student.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, NIH T32 appointee (2014-2016). PhD Thesis Defense 2017.

2011 – 2013 Namrata Jain, MD
Current Position: Assistant Professor, Columbia University.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

2011 – 2015 Nora Kochupurakkal, PhD
Current Position: Scientist, Amgen.
Career Stage: Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research, Young Investigator Award from the ATC (2014).

2012 – 2015 Hiro Nakayama, PhD
Current Position: Faculty/Scientist, Ehime University.
Career Stage: Fellow.
Mentoring Role: Co-Mentor/Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research.

2013 – 2014 Gulcin Demirci, MD. PhD
Current Position: Medical Director, Sanofi Genzyme.
Career Stage: Research Associate.
Mentoring Role: Research Advisor.
Accomplishments: Authored scholarship, Grant Award (Faculty Development Grant, Boston Children’s).

2017 – 2018 Sylvain Pagie, PhD
Current Position: Medical Student Training Scheme, University of Nantes, France.
Career Stage: Research Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Authored scholarship.

2017 – 2018 Timna Agur, MD
Current Position: Junior Faculty, Division of Nephrology and Hypertension, Rabin Medical Center, Belinson, Israel.
Career Stage: Research Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Authored scholarship.

2014 – 2018 Johannes Wedel, MD. PhD
Current Position: Research Associate, Boston Childrens Hospital; Instructor in Pediatrics, Harvard Medical School.
Career Stage: Research Fellow.
Mentoring Role: Research Advisor.
Accomplishments: Multiple authored scholarship of mentored research. Grants and Awards: DFG grant, Young Investigator Award from the ATC (2016), Young Investigator Awards from the Transplantation Society (2016), American Association of Immunologists Meeting Travel Award (2017), Young Investigator Award from the ATC (2018), American Association of Immunologists Meeting Travel Award (2018).

research associates + mentored faculty

Dr. Briscoe has also been active in the mentoring of junior faculty. He has sponsored or co-sponsored several faculty with junior career development grants and awards.

A full list of past research associates/mentored faculty and their current position and accomplishments can be found by clicking the link below:

Past Research Associates + Mentored Faculty

Markus Frank, MD 2001-2006
Current Position: Associate Professor of Pediatrics, Harvard Medical School, Boston, MA.
Career Stage when Training in the Laboratory: Instructor in Pediatrics.
Mentoring Role: Co- Mentor/Research Advisor.
Accomplishments: Co-Mentored K Award, elected member of the American Society of Clinical Investigation. Currently, R01-funded Investigator.

Soumitro Pal, PhD 2001-2009
Current Position: Associate Professor in Pediatrics, Harvard Medical School, Boston Children’s Hospital.
Career Stage when Training in the Laboratory: Instructor in Pediatrics.
Mentoring Role: Mentor/Research Advisor.
Accomplishments: NIH K01 Grant, AST Career Development grant, ASN Career Development Grant; Currently, NIH R01 and R21-funded Investigator.

Papia Banerjee, PhD 2009-2010
Current Position: Molecular and Cell Biologist, Boston, MA.
Career Stage when Training in the Laboratory: Staff Scientist.

Michael Seifert, MD 2011-2015
Current Position: Associate Professor, University of Alabama at Birmingham.
Career Stage when Training in the Laboratory: External Junior Faculty.
Mentoring Role: Co-Mentor.
Accomplishments: NIH K23 Career Development grant, Loan Repayment Grant (2012-2015). Currently, R01-funded Investigator.

Kevin Daly, MD 2012-2016
Current Position: Assistant Professor in Pediatrics, Harvard Medical School, Boston, MA.
Career Stage when Training in the Laboratory: Instructor in Pediatrics.
Mentoring Role: Mentor/Research Advisor.
Accomplishments: NIH K12 Award, NIH Loan Repayment Grant, AST Young Investigator Award. Currently, Co-PI on a DOD funded Clinical Trial Grant.

Gulcin Demirci, MD, PhD 2013-2014
Current Position: Medical Director, Sanofi Genzyme, Cambridge, MA.
Career Stage when Training in the Laboratory: Instructor in Pediatrics.

Chandra Ghosh, PhD 2016-2018
Current Position: Scientist, Roger Williams Medical Center.
Career Stage when Training in the Laboratory: Instructor in Pediatrics.
Mentoring Role: Mentor/Research Advisor.
Accomplishments: NIH R03 grant (Funded, Feb 2018).

Past Laboratory Assistants

Several laboratory assistants transitioned to higher educational studies including Law School and Medical School.

A full list of past laboratory assistants can be found by clicking the link below:

Past Laboratory Assistants

Christopher Geehan, JD 1996-2007

Chris served as the Briscoe Laboratory Manager and as the Manager of the newly formed Pediatric Transplantation Research Laboratories from 1996-2007. During this time, Chris attended Law School and passed the Massachussetts Bar in 2006. He currently works in the Office of General Counsel at Boston Children’s Hospital.

Kerith Koss, BS 2001-2003
Kerith served as a technician in the laboratory from 2001-2003. She left the laboratory to re-enter University as a graduate student in 2004 and she currently works at The Institute of Fine Arts in NY.

Katiana Calzadilla BS, MS 2006-2011
Katiana served as a technician and as Laboratory Manager from 2006-2011. During this time, she performed a Masters Thesis in Biotechnology at the Harvard Extension School, and was awarded a Masters in Liberal Arts in Extension Studies from Harvard University in 2011. She left the laboratory to join Pharma and develop her career in Clinical Studies.

Kayla Macleod, BS 2013-2014
Kayla served as a technician in the laboratory from 2013-2014. She left the laboratory to join a company developing gene therapy technologies.

Megan McGourty, BS 2011-2018
Megan joined as a research technician in the laboratory to learn and develop expertise in basic immunology and endothelial cell biology. She became the lab manager in 2014. She left the laboratory in 2018 to pursue personal interests.

Sarah Goldberg, BS 2016-2018
Sarah served as a research technician in the laboratory where she refined assays and expanded her scientific knowledge in human immunobiology. Her studies related to transplant immunology and she worked on techniques for the screening of novel pro-resolution molecules and the development of biomarker assays for use in human patients. Sarah left the laboratory to attend University and pursue a career in higher education.

Leah Jacobs, BA 2017-2018
Leah served as a research technician in the laboratory. She assisted with the generation and maintenance of transgenic animals and was involved in the maintenance of laboratory protocols. She left the laboratory to attend Dental School (University of Utah).

Mahima Poreddy, BA 2018-2020
Mahima served as a technician in the laboratory to develop expertise in basic immunology. She assisted with the generation and maintenance of transgenic animals and was involved in the maintenance of laboratory protocols. Mahima left the laboratory to attend Medical School (University of Vermont).

Evan Chernov, BS 2018-2020
Evan served as a technician in the laboratory to develop expertise in human immunological assays. He left the laboratory to attend Medical School (SUNY).

Allan Nip, BS 2020
Allan joined the laboratory to expand his interests in Molecular biomedicine and science. He left to join Novartis Pharma.

Past Students

A full list of past students can be found by clicking the link below:

Past Students

Graduate Students

Marlies Reinders 2000-2002
Mentored MD/PhD Thesis Trainee, University of Leiden, Holland

Esther Meijer 2006-2007
Masters MD student, University of Groningen, Holland

Michele Eisenga, MD 2013
Masters MD student, University of Groningen, Holland

Matthew Sheehan 2014-2015
NIDDK Med Student Research Program, Cornell University

Zoe Post 2014-2015
Masters MD student, University of Groningen, Holland

Josephine Koch 2016
Masters MD student, University of Groningen, Holland

Anne Linde Mak 2016
Masters MD student, University of Groningen, Holland

Summer Students

Gearoid McMahon 1998
MD student

Cathy Long 1997, 1998
BS student

Emily Chung 1997
BS student

Jeanette Reiners 2000
MD student

William Wong 1999-2004
BS and MD Student
Tufts University, Boston, MA

Christopher Burke 2002
BS student

Kevin Gaughan 2008, 2009
BS student

Matthew Sheehan 2009
BS, Premed student
Yale University, New Haven, CT

Sydney Keen 2014, 2015
BA Student
Fordham University, New York, NY

David Heron 2015
BS student
Xavier University, Cincinnati, OH (Harvard Summer Program)

Aderet Liss 2016, 2017
BA Biology
Yeshiva University, Stern College for Women
New York, NY

Chloe Li 2017
BA Neurobiology
Harvard University, Cambridge, MA

Daniel Goodman 2019
BA Biology, Minor in Economics
Lafayette College, Easton, PA