The Briscoe Laboratory

Transforming Clinical Care In Pediatric Transplantation Through Innovative Research

Our Research

The focus of the program is to perform basic research to further understand the molecular basis for chronic allograft rejection in children, the leading cause of graft failure following transplantation.

Members of the Transplant Research Program study the alloimmune response, the cellular basis for immunomodulation and roles for new molecules, novel receptors and signaling pathways that are causative of disease after transplantation.

The application of these discoveries clinically advance our approach to therapy and have high potential to limit complications following transplantation. Our overall goal is to transform clinical care through basic and translational research and discovery.

Click on the buttons below to learn more about our research and current projects:

David Briscoe, MD

David Briscoe is Professor of Pediatrics at Harvard Medical School, the Casey Lee Ball Chair in Transplantation, and Director of the Transplant Research Program at Boston Children’s Hospital.

He graduated from the Royal College of Surgeons Medical School in Ireland and completed his initial residency training in General Medicine and Pediatrics in Dublin, Ireland. He subsequently trained at the University of Colorado Health Sciences Center in Denver, Colorado, and at Boston Children’s Hospital. His initial postdoctoral research was performed in the laboratory of Dr. Jordan Pober, and a second postdoctoral fellowship was performed under the mentorship of Drs. Ramzi Cotran and Andrew Lichtman at the Brigham and Women’s Hospital, Harvard Medical School.

In 2013, he was appointed Director of the Transplant Research Program, and in 2015, he became the first incumbent Casey Lee Ball Chair in Transplantation. David is a an elected member of the National Physician-Scientist Honors Society, the American Society of Clinical Investigation (ASCI).

Research Opportunities

open positions

Positions are available for highly motivated undergraduate and post-graduate trainees
with an interest and expertise in cellular and molecular immunobiology.

If interested we would love to hear from you, please get in touch.


PubMed Listings

Click below for a complete listing of Briscoe Laboratory Publications

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