The Briscoe Laboratory


 

 

 

 


Principal Investigator

 

David Briscoe, MD

 

David graduated from the Royal College of Surgeons Medical School in Ireland and completed his initial residency training in General Medicine and Pediatrics in Dublin, Ireland. He subsequently trained at the University of Colorado Health Sciences Center in Denver, Colorado, and at Boston Children's Hospital. His initial postdoctoral research was performed in the laboratory of Dr. Jordan Pober, and a second postdoctoral fellowship was performed under the mentorship of Drs. Ramzi Cotran and Andrew Lichtman at the Brigham and Women's Hospital, Harvard Medical School. Dr. Briscoe's first faculty appointment was within the Division of Nephrology at the Boston Children's Hospital, where he established his research effort. In 2013, he was appointed Director of the Transplant Research Program, and in 2015, he became the first incumbent Casey Lee Ball Chair in Transplantation.

Other activities:
Councilor, International Pediatric Transplant Association
Standing member of the NIH TTT study section
Senior Editor, Transplantation Direct


Administrator

 

Nicole Mitton

 

Nicole provides administrative support, including grants management, for the Briscoe Lab. As the Transplant Research Program grows, she will support the activities of all PIs within the program. Nicole previously worked as a grant writer specializing in public health, human services, and higher education. She received her MA in Regional Studies from Harvard University.


Mentored Faculty

 

Chandra Ghosh, PhD

 

Chandra graduated as a pharmacologist in Calcutta, India and subsequently performed his PhD in the biological sciences (inflammation and immunology) at St. John’s University in New York. He has had a longstanding interest in renal disease and is particularly interested in renal fibrosis mechanisms. His work in the Briscoe Laboratory involves the hypothesis that disruption of the Tie2-angiopoeitin axis within the microvasculature of an allograft is pathophysiological in the process of chronic allograft rejection.


Research Fellows

Timna Agur, MD

 

Timna is a Visting Research Fellow from Israel. She is a clinical nephrologist for Clalit Heath Services, the largest health service organization in the country. She is joining the Briscoe Laboratory to develop skills in translational research and transplantation.

 

Kaifeng Liu, MD

 

Kaifeng graduated from Tongji Medical University School of Medicine in 1986. He worked in southern China as a clinical surgeon prior to moving the USA. He trained in research, and specifically in the use of animal surgical models at the Universities of Michigan, Chicago and Emory, prior to joining Dr. Gary Visner’s laboratory in the Pulmonary Division at Children’s Hospital Boston. He works with the Briscoe laboratory and other members of the Transplant Research Program to support ongoing collaborations and studies using animal models of lung, heart and skin transplantation. His current interests relate to the analysis of distinct roles for regulators of the immune response, and how this is important in the development of chronic rejection.

Sylvain Pagie, PhD

 

Sylvain received his PhD from Université de Nantes in 2017. He seeks to develop his expertise in endothelial cell immunobiology.

 

Johannes Wedel, MD, PhD

 

Johannes received his MD in 2012 from the Heidelberg University, Germany. During his training, he was a member of an International Research Training Group that fosters interactions between the Medical Faculty of Mannheim, Heidelberg University, Germany and the University of Groningen, Netherlands. He recently completed and received his Ph.D. at the University of Groningen. His Ph.D. studies involved an investigation of the effects of N-octanoyl-dopamine in alloimmunity, as well as in cellular protection in models of brain death and organ storage. He is particularly interested in transplantation immunology and joined Dr. Briscoe’s laboratory to gain additional experience in the investigation of intracellular signaling pertaining to T cell activation and allograft rejection.

Laboratory Assistants

Evelyn Flynn, BS, MA

 

Evelyn received her MA degree in biology from Boston University in 1990. She has worked in several research areas at Children’s Hospital Boston over the past 15 years and has a special interest in vascular biology and orthopedic research. She specializes in immunohistochemistry and electron microscopy and is a co-author on more than fifty publications. Evelyn is an experienced senior technologist in the laboratory, and enjoys working with fellows in teaching general laboratory techniques as well as histology/immunohistochemistry.

 

Megan McGourty, BS

 

Megan received her Bachelor’s degree in Biology from Bridgewater State University in 2010. She joined the Briscoe Laboratory as a research technician to learn and develop expertise in basic immunology and endothelial cell biology. She is interested in cell culture and molecular biology techniques, as well as the generation and maintenance of transgenic animals. Megan interacts with all fellows on a daily basis and is involved in the maintenance laboratory protocols. Megan is also involved in the processing of human blood samples from patients involved in multicenter CTOT studies that are ongoing in the laboratory.

 

Sarah Goldberg, BS

 

Sarah received her Bachelors degree in Biochemistry from Northeastern University in 2015. Towards the end of her studies, she developed an interest in Immunology and decided to pursue that interest post-graduation. She initially worked at Boston University and developed expertise in immunological techniques and recently joined the Briscoe Lab to refine assays and to expand her scientific knowledge in human immunobiology. In the Briscoe lab, her current studies relate to transplant immunology and she is working on techniques for the screening of novel pro-resolution molecules and developing biomarker assays for use in human patients.


Past Research Associates/Mentored Faculty

Soumitro Pal, PhD 2001-2009
Current Position: Associate Professor in Pediatrics, Harvard Medical School, Boston Children’s Hospital

Gulcin Demirci, MD, PhD 2013-2014
Current Position: Medical Director, Sanofi Genzyme, Cambridge, MA
Papia Banerjee, PhD 2009-2010
Current Position: Molecular and Cell Biologist, Boston, MA

Kevin Daly, MD 2012-2016
Current Position: Assistant Professor in Pediatrics, Harvard Medical School, Attending in Cardiology, Boston Children’s Hospital

Past Research Fellows

Michelle Baum, MD 1994-1995
Assistant Professor of Pediatrics,
Harvard Medical School,
Children’s Hospital Boston,
Boston, MA

Ross Reul, MD 1995-1997
Cardiovascular Surgeon,
Houston Methodist Cardiovascular Surgery Associates,
Houston, TX

Stephen Alexander, MD 1995-1998
Associate Professor,
Paediatrics and Child Health,
Children’s Hospital Westmead,
Sydney, Australia

Vikas Dharnidharka, MD 1996-1998
Professor, Pediatrics
Chief, Division of Pediatric Nephrology,
Washington University School of Medicine in St. Louis,
St. Louis, MO

Mark Denton, MD 1996-1999
Consultant Nephrologist,
Beaumont Hospital, Ireland

Peter Shaw, MD 1998-2000
Deceased

Andrea Exeni, MD 1998-2000
Dept Head, Pediatric Nephrology,
Hospital Universitario Austral,
Buenos Aires, Argentina

Michael Melter, MD 1998-2000
Head of the Dept of Pediatrics and Adolescent Medicine,
Children’s Hospital,
Regensburg, Germany

Markus Frank, MD 1999-2001
Associate Professor in Medicine,
Boston Children’s Hospital,
Boston, MA

 

Masayuki Sho, MD, PhD 1999- 2002
Associate Professor,
Dept. of Surgery,
Nara Medical University,
Nara, Japan

Dmitry Samsonov, MD 1999-2002
Pediatric Nephrologist,
Westchester Medical Center,
Valhalla, NY


Ingrid Vos, PhD 2000-2002
Staff Scientist,
Utrecht Veterinary College,
Utrecht, The Netherlands

Marlies Reinders, MD, PhD 2000-2002
Professor of Medicine,
Dept of Nephrology and Transplantation,
University of Leiden,
Leiden, The Netherlands

 

Peter Lapchak, PhD 2000-2003
Lecturer in Medicine,
Harvard Medical School,
Boston, Massachusetts

 

Stefan Kiessling, MD 2002-2004
Chief, Division of Pediatric Nephrology,
University of Kentucky Healthcare,
Lexington, KY

Stuart Robertson, MD 2002-2005
Consultant Physician,
Betsi Cadwaladr University Health Board,
Wales, UK

 

Jesse Flaxenburg, MD 2002-2005
Consultant Nephrologist,
Pikes Peak Nephrology,
Colorado Springs, CO

 

Atsushi Izawa, MD, PhD 2002-2005
Research Scientist,
Department of Cardiovascular Medicine,
Shinshu University School of Medicine,
Nagano, Japan


Zdenka Haskova, MD, PhD 2003-2005
Medical Director, Genentech,
San Francisco, CA

Sreevinas Laxmanan, PhD 2003-2006
Senior Scientist, Sanofi Genzyme,
Cambridge, MA

 

Gwen Boulday, PhD 2002-2006
Research Scientist, INSERM,
Paris, France

 

Olivier Dormond, MD, PhD 2003-2007
Group Leader,
Research Laboratory of Visceral Surgery Department, CHUV,
Vaude, Switzerland

 

Monika Edelbauer, MD 2006-2008
PD MD, Medical University Innsbruck,
Innsbruck, Austria


Alan Contreras, MD 2003-2008
Specialist in General Surgery,
Hospital Angeles Pedregal,
CDMX, Mexico


Andre Hoerning, MD 2006-2008
Senior Physician,
Universitätsklinikum Erlangen,
Erlangen, Germany

Xiao Wu, MD, PhD 2006-2010
Electives/Clinical Training in Pathology,
Framingham, MA

 

Aninda Basu, PhD 2005-2009
Department of Surgery,
University of Illinois at Chicago,
Chicago, IL

 

Dipak Datta, PhD 2003-2010
Scientist E-I,
Central Drug Research Institute,
Lucknow, India

 

Maria Stack, MB 2008-2010
Nephrology Consultant,
Temple Street Children’s University Hospital,
Dublin, Ireland

 

Gearoid McMahon, MD 2008-2010
Instructor in Medicine,
Brigham and Women’s Hospital,
Boston, MA

 

Tatsuichiro Seto, MD, PhD 2008-2011
Staff Cardiovascular Surgeon,
Department of Surgery,
Shinshu University,
Shinshu, Japan

 

Sarah Bruneau, PhD 2009-2013
Research Scientist, INSERM,
Nantes, France

 

Namrata Jain, MD 2011-2013
Pediatric Nephrologist,
New York-Presbyterian Morgan Stanley Children’s Hospital,
New York, NY

 

Craig Woda MD, PhD 2010-2013
Assistant in Medicine,
Boston Children’s Hospital,
Boston, MA


Nora Kochupurakkal, PhD 2011-2015
Scientist, Amgen
Cambridge, MA


Leo Boneschansker, MD, PhD 2010-2017
Resident in Medicine,
Massachusetts General Hospital
Boston, MA

 
Past Laboratory Assistants

Christopher Geehan, JD 1996-2007
Chris served as the Briscoe Laboratory Manager and as the Manager of the newly formed Pediatric Transplantation Research Laboratories from 1996-2007. During this time, Chris attended Law School and passed the Massachussetts Bar in 2006. He currently works in the Intellectual Property Office of Children’s Hospital Boston as a member of their Legal team.
Katiana Calzadilla BS, MS 2006-2011
Katiana served as a technician and as Laboratory Manager from 2006-2011. During this time, she performed a Masters Thesis in Biotechnology at the Harvard Extension School, and was awarded a Masters in Liberal Arts in Extension Studies from Harvard University in 2011. She left the laboratory to join Pharma and develop her career in Clinical Studies.
Kerrith Koss, BS 2001-2003
Kerrith served as a technician in the laboratory from 2001-2003. She left the laboratory to re-enter University as a graduate student in 2004 and she is currently a project conservator at Brooklyn Museum.
Kayla Macleod, BS 2013-2014
Kayla served as a technician in the laboratory from 2013-2014. She left the laboratory to join a company developing gene therapy technologies.
 
Past Students


Graduate Students

Marlies Reinders 2000-2002
Mentored MD/PhD Thesis Trainee,
University of Leiden, Holland
Matthew Sheehan 2014-2015
NIDDK Med Student Research Program
Cornell University
Anne Linde Mak 2016
Masters MD student,
University of Groningen, Holland
Esther Meijer 2006-2007
Masters MD student,
University of Groningen, Holland
Zoe Post 2014-2015
Masters MD student,
University of Groningen, Holland

Michele Eisenga, MD 2013
Masters MD student,
University of Groningen, Holland
Josephine Koch 2016
Masters MD student,
University of Groningen, Holland

Summer Students

Gearoid McMahon 1998
MD student

Cathy Long 1997, 1998
BS student

Emily Chung 1997
BS student

 

Jeanette Reiners 2000
MD student

William Wong 1999-2004
BS and MD Student
Tufts University, Boston, MA

Christopher Burke 2002
BS student

Kevin Gaughan 2008, 2009
BS student

 

Matthew Sheehan 2009
BS, Premed student
Yale University, New Haven, CT

Sydney Keen 2014, 2015
BA Student
Fordham University, New York, NY

David Heron 2015
BS student
Xavier University, Cincinnati, OH (Harvard Summer Program)

Aderet Liss 2016, 2017
BA Biology
Yeshiva University, Stern College for Women
New York, NY

The Briscoe Laboratory, Transplant Research Program,

Boston Children’s Hospital, and Harvard Medical School