David Briscoe is Professor of Pediatrics at Harvard Medical School, the Casey Lee Ball Chair in Transplantation, and Director of the Transplant Research Program at Boston Children’s Hospital. He is also an elected member of the National Physician-Scientist Honors Society, the American Society of Clinical Investigation (ASCI). Research in the Briscoe Laboratory focuses on intragraft mechanisms of allograft rejection. Ongoing projects address questions about endogenous signaling within vascular endothelial cells and T cells that inhibit inflammation and rejection. The laboratory also has a long-standing interest in VEGF-VEGFR interactions and their function in the rejection process. The ultimate goal of our research is to understand the complexity of chronic allograft rejection, to identify molecules that have therapeutic potential to inhibit alloimmune-mediated graft injury.